Endocrine Abstracts

The primary treatment of adrenocortical carcinoma (ACC) is surgery and the adrenolytic mitotane. In order to test the effect of everolimus, nilotinib, imatinib and zoledronic Acid/ZOL in combination with mitotane were used ACC cell line NCI-H295R, in monolayer (2D) and spheroid (3D) cell cultures. The cytotoxicity promoted by treatments was analyzed by MTS and Cell Death assays. These assays were also performed intending of use them to test drugs in tumor cell cultures from pa...

Abstract: Congenital hypogonadotropic hypogonadism (CHH) is characterized by isolated GnRH deficiency in the absence of central anatomical causes. Classically considered to be a permanent disorder, CHH reversal has been reported in up to 15% of cases. However, reversal may not always be life-long, as hypogonadism relapse can occur in a subset of patients. Criteria for reversal normalization of circulating sex steroids, and spontaneous fertility. We report a 26-yrs-old man, who...